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CS-W001157 4
Total: USD 88.00

2-Bromo-3-(trifluoromethyl)pyridine

  • CAS No. 175205-82-0

  • Cat. No. CS-W013033
  • Purity≥98%
  • MDL No.MFCD00153084

*For research and further manufacturing use only, not for direct human use.

2-Bromo-3-(trifluoromethyl)pyridine|CS-W013033

Structure of 175205-82-0

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General Information

  • CAS No. 175205-82-0
  • Cat. No. CS-W013033
  • Purity ≥98%
  • MDL No. MFCD00153084
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrF₃N
  • Molecular Weight 226.00
  • Synonym(s) 2-Bromo-alpha,alpha,alpha-trifluoro-3-picoline; 2-Bromo-3-(trifluoromethyl)pyridine
  • SMILES BrC1=NC=CC=C1C(F)(F)F

Description

2-Bromo-3-(trifluoromethyl)pyridine features a trifluoromethyl group flanking a brominated pyridine core, delivering enhanced electron-withdrawing character and improved metabolic stability. This structural motif enables direct incorporation into cross-coupling reactions, facilitating rapid access to functionalized heteroaryl architectures in medicinal chemistry and materials science.

Application

2-Bromo-3-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry and catalytic synthesis. The bromine moiety enables palladium-catalyzed cross-coupling reactions, while the trifluoromethyl group imparts enhanced metabolic stability and lipophilicity. Its bench-stable nature and compatibility with diverse reaction conditions facilitate efficient construction of complex heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05,GHS06
Signal Word : Danger
UN#: 2926
Class : 4.1 (6.1)
Packing Group : Ⅲ
Hazard Statements : H228-H300-H315-H318-H335
Precautionary Statements : P210-P240-P241-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.8629
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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