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Structure of 175278-00-9
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1-Iodo-2-(trifluoromethoxy)benzene features a trifluoromethoxy group positioned ortho to the iodine atom, imparting enhanced stability and electron-withdrawing character. This configuration facilitates efficient cross-coupling reactions under standard conditions, enabling reliable C–C bond formation in synthetic sequences. The molecule exhibits excellent bench-stability and compatibility with palladium-catalyzed transformations.
1-Iodo-2-(trifluoromethoxy)benzene serves as a versatile aryl halide building block in palladium-catalyzed cross-coupling reactions. Its trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, making it valuable for medicinal chemistry applications. The iodide functionality enables efficient coupling with boronic acids, amines, and other nucleophiles under mild conditions, facilitating rapid access to complex biaryl and heterocyclic scaffolds. Bench-stable and readily purified by distillation, it functions reliably in high-throughput synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: