2,3,4-Trifluorobenzenesulfonyl chloride

Name: 2,3,4-Trifluorobenzenesulfonyl chloride
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CAS No. 175278-08-7
Cat. No. CS-0132312
Purity≥97%
MDL No.MFCD00102573

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,3,4-Trifluorobenzenesulfonyl chloride|CS-0132312

Structure of 175278-08-7

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General Information

CAS No. 175278-08-7
Cat. No. CS-0132312
Purity ≥97%
MDL No. MFCD00102573
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂ClF₃O₂S
Molecular Weight 230.59
Synonym(s) Benzenesulfonyl chloride, 2,3,4-trifluoro- (9CI)
SMILES O=S(C1=CC=C(F)C(F)=C1F)(Cl)=O

Description

2,3,4-Trifluorobenzenesulfonyl chloride features a trifluorinated aromatic ring that enhances electrophilicity and stability. This sulfonyl chloride derivative enables efficient sulfonation of nucleophiles under mild conditions, offering high reactivity with amines and alcohols. The electron-withdrawing fluorine atoms stabilize the sulfonyl group while improving solubility in organic media.

Application

2,3,4-Trifluorobenzenesulfonyl chloride serves as a highly effective sulfonylating agent for the synthesis of trifluoromethyl-substituted sulfonamides and sulfonates. Its enhanced electrophilicity due to the electron-withdrawing trifluoromethyl group enables efficient reaction with amines and alcohols under mild conditions. The reagent exhibits good bench stability and facilitates clean, high-yielding transformations with broad functional group tolerance, making it a practical choice for constructing fluorinated building blocks in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3265
Class : 8	Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

TPSA 34.14
LogP 2.0314
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Sulfonyl Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2,3,4-Trifluorobenzenesulfonyl chloride

CAS No. 175278-08-7

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