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Structure of 176508-81-9
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4-Cyano-3-fluorobenzoic acid features a strategically positioned cyano and fluorine group flanking a carboxylic acid, enabling enhanced electron withdrawal and metabolic stability. This combination supports direct incorporation into bioactive scaffolds and facilitates efficient derivatization in medicinal chemistry campaigns under standard conditions.
4-Cyano-3-fluorobenzoic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation of both nitrile and fluorinated aromatic functionalities into target molecules. Its carboxylic acid group facilitates straightforward amidation, esterification, and coupling reactions, while the ortho-fluoro and cyano substituents provide excellent regioselectivity in electrophilic substitution and transition-metal-catalyzed transformations. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for high-throughput synthesis and process development workflows.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H318-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: