5-Bromo-2-chloro-1,3-difluorobenzene

Name: 5-Bromo-2-chloro-1,3-difluorobenzene
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 176673-72-6
Cat. No. CS-0134653
Purity≥97%
MDL No.MFCD00143420

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5-Bromo-2-chloro-1,3-difluorobenzene|CS-0134653

Structure of 176673-72-6

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Description

5-Bromo-2-chloro-1,3-difluorobenzene is a fluorinated aromatic building block featuring orthogonal halogen handles for selective cross-coupling. The para-fluorine and meta-bromo positions enable sequential functionalization, while the ortho-chloro group offers complementary reactivity. This electron-deficient scaffold integrates readily into complex molecular architectures under standard palladium-catalyzed conditions.

Application

5-Bromo-2-chloro-1,3-difluorobenzene serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The strategic placement of bromo, chloro, and difluoro substituents supports sequential functionalization, with the bromo group typically participating first in Suzuki or Stille couplings. Its bench-stable nature and compatibility with standard purification methods make it ideal for multi-step synthesis and API intermediate development.

General Information

CAS No. 176673-72-6
Cat. No. CS-0134653
Purity ≥97%
MDL No. MFCD00143420
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂BrClF₂
Molecular Weight None
Synonym(s) 5-difluorobromobenzene
SMILES FC1=C(Cl)C(F)=CC(Br)=C1

Computational Chemistry Data

TPSA 0
LogP 3.3807
H_Acceptors 0
H_Donors 0
Rotatable_Bonds 0

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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5-Bromo-2-chloro-1,3-difluorobenzene

CAS No. 176673-72-6

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