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Structure of 455-24-3
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4-(Trifluoromethyl)benzoic acid was used in the synthesis of salicylanilide 4-(trifluoromethyl)benzoates via N,N-dicyclohexylcarbodiimide coupling in dry N,N-dimethylformamide. It was used as internal standard during the ultra trace analysis of fluorinated aromatic carboxylic acids by GC/MS method.
4-(Trifluoromethyl)benzoic acid serves as a versatile building block in medicinal chemistry and materials science, enabling efficient incorporation of a strongly electron-withdrawing trifluoromethyl group into aromatic scaffolds. Its carboxylic acid functionality facilitates direct amidation, esterification, and coupling reactions, while the para-trifluoromethyl substituent enhances metabolic stability and lipophilicity. The compound exhibits excellent bench stability and is readily purified by recrystallization, making it well-suited for high-throughput synthesis and scale-up applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: