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Structure of 177842-14-7
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This difluoromethoxy-substituted aniline derivative features a benzene ring bearing a para-difluoromethoxy group and a primary amine at the benzylic position. The electron-withdrawing nature of the difluoromethoxy moiety enhances amine basicity while improving metabolic stability, making this compound valuable for medicinal chemistry applications requiring enhanced membrane permeability and resistance to oxidative degradation.
(4-(Difluoromethoxy)phenyl)methanamine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive compounds through standard amine functionalization. Its difluoromethoxy substituent enhances metabolic stability and modulates lipophilicity, while the primary amine facilitates conjugation reactions, reductive amination, and peptide coupling. The compound exhibits good bench stability and is readily purified by chromatography or crystallization, supporting scalable synthesis and integration into diverse heterocyclic scaffolds.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 2735
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314-H318
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Precautionary Statements : P280-P301+P330+P331-P302+P352-P304+P340
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Lot numbers can be found on the outside label of a product: