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CS-W001157 4
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2-Amino-2-thiazoline

  • CAS No. 1779-81-3

  • Cat. No. CS-0074129
  • Molecule weight102.16
  • Purity≥97%
  • MDL No.MFCD00005313

*For research and further manufacturing use only, not for direct human use.

2-Amino-2-thiazoline|CS-0074129

Structure of 1779-81-3

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General Information

  • CAS No. 1779-81-3
  • Cat. No. CS-0074129
  • Purity ≥97%
  • MDL No. MFCD00005313
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₆N₂S
  • Molecular Weight 102.16
  • Synonym(s) None
  • SMILES N1=C(SCC1)N

Description

4,5-Dihydro-1,3-thiazol-2-amine serves as a versatile scaffold in medicinal chemistry, featuring a reactive thiazole nitrogen and a reducible C4–C5 bond. This heterocycle integrates readily into bioactive molecules, offering enhanced solubility and metabolic stability. Its amine functionality enables direct derivatization for targeted drug discovery applications.

Application

4,5-Dihydro-1,3-thiazol-2-amine serves as a versatile scaffold in medicinal chemistry, enabling efficient access to thiazole-containing heterocycles. Its reactive NH group facilitates nucleophilic substitution and amidation, while the dihydrothiazole ring exhibits bench stability and compatibility with common functional groups. This compound functions as a key building block in the synthesis of kinase inhibitors and other bioactive molecules, offering predictable reactivity in standard coupling protocols.

Synthesis

  • Route1
    • In-stock
      2-Bromoethylammonium bromide|CS-W008659
      2576-47-8
    • null|null
      17356-08-0
    • ~88%
    • In-stock
      2-Amino-2-thiazoline|CS-0074129
      1779-81-3

    References

    • Pathak, Uma; Bhattacharyya, Shubhankar; Dhruwansh, Vishwanath; Pandey, Lokesh Kumar; Tank, Rekha; Suryanarayana, Malladi V. S. Green Chemistry, 2011 , vol. 13, # 7 p. 1648 - 1651
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 79, p. 5667,5670
  • Route3
    • 2-Chloroethanamine hydrochloride Ifosfamide  Impurity|CS-0229451
      870-24-6
    • null|null
      333-20-0
    • ~%
    • In-stock
      2-Amino-2-thiazoline|CS-0074129
      1779-81-3

    References

    • Journal of the American Chemical Society, , vol. 63, p. 3124

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.38
  • LogP   0.0479
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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