(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid

Name: (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid
Brand: ChemScene
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CAS No. 178119-93-2
Cat. No. CS-0100970
Purity≥95%
MDL No.MFCD02682475

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(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid|CS-0100970

Structure of 178119-93-2

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Description

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid is a bench-stable, moisture-tolerant chiral building block featuring a fluorenylmethyl carbamate (Fmoc) protecting group. This configuration enables direct incorporation into peptide synthesis workflows, where the pendant phenolic hydroxyl supports downstream derivatization or conjugation.

Application

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid serves as a valuable chiral building block for the synthesis of peptidomimetics and bioactive heterocycles. The Fmoc-protected amino group enables efficient coupling in solid-phase peptide synthesis, while the pendant phenolic hydroxyl offers a site for derivatization or orthogonal functionalization. Its bench-stable crystalline nature facilitates handling and purification, supporting scalable preparation of complex pharmaceutical intermediates.

General Information

CAS No. 178119-93-2
Cat. No. CS-0100970
Purity ≥95%
MDL No. MFCD02682475
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₃H₁₉NO₅
Molecular Weight 389.40
Synonym(s) Nα-Fmoc-(4-hydroxy)-D-phenylglycine
SMILES O=C([C@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C4=CC=C(O)C=C4)O

Computational Chemistry Data

TPSA 95.86
LogP 4.0566
H_Acceptors 4
H_Donors 3
Rotatable_Bonds 5

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H317-H319
Precautionary Statements : P261-P264-P272-P280-P302+P352-P362+P364-P501

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Glycine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid

CAS No. 178119-93-2

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