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Structure of 178312-47-5
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Ethyl 4,4-difluorocyclohexanecarboxylate features a rigid cyclohexane core with two fluorine atoms at the C4 position, enhancing electron withdrawal and conformational stability. This difluorinated ester integrates readily into asymmetric synthesis workflows, serving as a key chiral building block for medicinal chemistry applications.
Ethyl 4,4-difluorocyclohexanecarboxylate serves as a versatile building block in medicinal chemistry and asymmetric synthesis. The geminal difluoride moiety imparts enhanced metabolic stability and modulates lipophilicity, while the ester group enables subsequent transformations including hydrolysis, reduction, or coupling reactions. Its cyclohexane scaffold provides conformational rigidity, facilitating stereocontrolled synthesis. Bench-stable and readily purified by standard chromatography, it functions effectively in multistep sequences for drug discovery and API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: