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Structure of 178421-22-2
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Methyl 6-chloro-5-methylpicolinate is a bench-stable, electron-deficient heterocyclic ester featuring a chlorinated pyridine core with orthogonal methyl and ester functionalities. This structural motif enables direct incorporation into cross-coupling cascades and serves as a key scaffold for medicinal chemistry libraries.
Methyl 6-chloro-5-methylpicolinate serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling direct functionalization at the pyridine ring due to orthogonal reactivity of the chloro and methyl groups. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling reactions facilitate efficient construction of complex scaffolds. The ester functionality supports subsequent transformations including hydrolysis and amidation, making it valuable for API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: