Tert-butyl 7,7-difluoro-3,9-diazaspiro[5.5]Undecane-3-carboxylate

Name: Tert-butyl 7,7-difluoro-3,9-diazaspiro[5.5]Undecane-3-carboxylate
Brand: ChemScene
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CAS No. 1784848-04-9
Cat. No. CS-0500295
Purity≥97%
MDL No.None

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Tert-butyl 7,7-difluoro-3,9-diazaspiro[5.5]Undecane-3-carboxylate|CS-0500295

Structure of 1784848-04-9

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General Information

CAS No. 1784848-04-9
Cat. No. CS-0500295
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₂₄F₂N₂O₂
Molecular Weight 290.35
Synonym(s) None
SMILES CC(C)(C)OC(=O)N1CCC2(CCNCC2(F)F)CC1

Description

Tert-butyl 7,7-difluoro-3,9-diazaspiro[5.5]undecane-3-carboxylate features a rigid spirocyclic core with dual fluorine atoms at the 7-position, enhancing metabolic stability and lipophilicity. The tert-butyl ester group enables convenient deprotection under mild acidic conditions. This scaffold integrates readily into bioactive molecules, particularly in medicinal chemistry campaigns targeting CNS disorders and kinase inhibitors.

Application

Tert-butyl 7,7-difluoro-3,9-diazaspiro[5.5]undecane-3-carboxylate serves as a robust spirocyclic scaffold for medicinal chemistry and catalytic synthesis. The difluoromethyl group enhances metabolic stability and modulates electronic properties, while the tert-butyl ester enables straightforward deprotection under mild acidic conditions. This compound functions as a versatile building block in the construction of complex nitrogen-containing heterocycles and supports functional group tolerance in standard coupling and cyclization reactions.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 41.57
LogP 2.6323
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Spirol Rings compounds

Key Words

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Tert-butyl 7,7-difluoro-3,9-diazaspiro[5.5]Undecane-3-carboxylate

CAS No. 1784848-04-9

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