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Structure of 1788085-46-0
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rel-(2R,3R)-2-[Bis(1,1-dimethylethyl)phosphinyl]-3-(1,1-dimethylethyl)-2,3-dihydro-4-methoxy-1,3-benzoxaphosphole is a sterically shielded phosphine oxide derivative featuring a chiral benzoxaphosphole core. This bench-stable reagent integrates a methoxy-substituted heterocycle with bulky tert-butyl groups that enhance solubility and resistance to oxidation. The configuration at the 2R,3R centers ensures predictable stereochemical control in asymmetric synthesis. It serves as a robust ligand precursor for transition metal catalysis and enables efficient coupling reactions under mild conditions.
rel-(2R,3R)-2-[Bis(1,1-dimethylethyl)phosphinyl]-3-(1,1-dimethylethyl)-2,3-dihydro-4-methoxy-1,3-benzoxaphosphole serves as a stable, bench-ready chiral phosphine ligand precursor. Its sterically encumbered diisopropylphosphinyl group enables efficient coordination in transition metal catalysis, while the methoxy-substituted benzoxaphosphole core enhances solubility and functional group tolerance. This scaffold facilitates stereoselective transformations in cross-coupling and asymmetric synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: