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Structure of 17920-23-9
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Diethyl 2-(prop-2-yn-1-yl)malonate features a propargylic linkage that enables efficient conjugate additions and Sonogashira couplings. This bench-stable diester integrates readily into synthetic sequences requiring nucleophilic or transition-metal-catalyzed C–C bond formation, offering high functional group tolerance and clean reaction profiles under standard conditions.
Diethyl 2-(prop-2-yn-1-yl)malonate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized heterocycles and carbocyclic scaffolds. Its terminal alkyne moiety facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the malonate ester group supports facile deprotonation and nucleophilic substitution. The compound exhibits excellent bench stability and compatibility with diverse reaction conditions, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: