(S)-2-(Difluoromethyl)morpholine hydrochloride

Name: (S)-2-(Difluoromethyl)morpholine hydrochloride
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CAS No. 1802989-03-2
Cat. No. CS-0781862
Molecule weight173.59
Purity≥98%
MDL No.None

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(S)-2-(Difluoromethyl)morpholine hydrochloride|CS-0781862

Structure of 1802989-03-2

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General Information

CAS No. 1802989-03-2
Cat. No. CS-0781862
Purity ≥98%
MDL No. None
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₀ClF₂NO
Molecular Weight 173.59
Synonym(s) None
SMILES FC([C@@H]1CNCCO1)F.[H]Cl

Description

(S)-2-(Difluoromethyl)morpholine hydrochloride is a bench-stable, moisture-tolerant chiral building block featuring a difluoromethyl group attached to a morpholine core. This configuration delivers enhanced metabolic stability and favorable lipophilicity, enabling efficient incorporation into bioactive molecules. The hydrochloride salt improves solubility and handling in synthetic workflows.

Application

(S)-2-(Difluoromethyl)morpholine hydrochloride serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. Its difluoromethyl group imparts enhanced metabolic stability and modulates lipophilicity, while the morpholine core offers favorable solubility and hydrogen-bonding capacity. The hydrochloride salt ensures excellent bench stability and ease of handling, facilitating straightforward incorporation into standard coupling and functionalization reactions.

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

TPSA 21.26
LogP 0.6617
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Morpholine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(S)-2-(Difluoromethyl)morpholine hydrochloride

CAS No. 1802989-03-2

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