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CS-W001157 4
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Methyl 6-amino-5-bromonicotinate

  • CAS No. 180340-70-9

  • Cat. No. CS-W003325
  • Purity≥98%
  • MDL No.MFCD06659561

*For research and further manufacturing use only, not for direct human use.

Methyl 6-amino-5-bromonicotinate|CS-W003325

Structure of 180340-70-9

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General Information

  • CAS No. 180340-70-9
  • Cat. No. CS-W003325
  • Purity ≥98%
  • MDL No. MFCD06659561
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BrN₂O₂
  • Molecular Weight 231.05
  • Synonym(s) Methyle6-amino-5-bromonicotinate
  • SMILES O=C(C1=CC(Br)=C(N)N=C1)OC

Description

Methyl 6-amino-5-bromonicotinate features a brominated pyridine core with a strategically positioned amino group, enabling direct functionalization in late-stage synthesis. This bench-stable derivative integrates readily into heterocyclic scaffolds, offering enhanced reactivity for pharmaceutical intermediates and agrochemical development under standard conditions.

Application

Methyl 6-amino-5-bromonicotinate serves as a versatile building block in medicinal chemistry, enabling direct functionalization at both the amino and bromo sites. The ortho-halogenation facilitates palladium-catalyzed cross-coupling reactions, while the free amine allows for acylation, alkylation, or heterocycle formation. Its bench-stable nature and compatibility with standard protecting group strategies make it ideal for modular synthesis of complex scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   65.21
  • LogP   1.2129
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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