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1-(1-Methylazetidin-3-yl)methanamine dihydrochloride

  • CAS No. 1803609-11-1

  • Cat. No. CS-0183702
  • Molecule weight173.08
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(1-Methylazetidin-3-yl)methanamine dihydrochloride|CS-0183702

Structure of 1803609-11-1

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General Information

  • CAS No. 1803609-11-1
  • Cat. No. CS-0183702
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₄Cl₂N₂
  • Molecular Weight 173.08
  • Synonym(s) C-(1-Methyl-azetidin-3-yl)-methylamine dihydrochloride
  • SMILES CN1CC(C1)CN.Cl.Cl

Description

This dihydrochloride salt features a methylazetidinylmethylamine scaffold with enhanced solubility and stability under standard conditions. The protonated amine centers facilitate efficient coupling in peptide synthesis and offer favorable pharmacokinetic properties. This compound serves as a key building block for bioactive molecule development.

Application

1-(1-Methylazetidin-3-yl)methanamine dihydrochloride serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient access to nitrogen-containing heterocycles and amine-directed conjugation. The tertiary amine functionality offers strong basicity and enhanced solubility, while the azetidine ring provides conformational rigidity and improved metabolic stability. Its bench-stable dihydrochloride salt form facilitates handling, purification, and incorporation into diverse synthetic sequences, including peptide coupling and macrocyclization reactions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   0.3503
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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