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CS-W001157 4
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3-Bromo-2-(trifluoromethyl)pyridin-4-amine

  • CAS No. 1805511-17-4

  • Cat. No. CS-0492299
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Bromo-2-(trifluoromethyl)pyridin-4-amine|CS-0492299

Structure of 1805511-17-4

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Description

3-Bromo-2-(trifluoromethyl)pyridin-4-amine features a trifluoromethyl group that enhances electron deficiency and metabolic stability, while the bromo and amine functionalities enable direct coupling in cross-coupling reactions. This pyridine scaffold serves as a key building block for pharmaceutical intermediates and functional materials.

Application

3-Bromo-2-(trifluoromethyl)pyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive bromo group and electron-deficient pyridine core. The trifluoromethyl and amino functionalities provide orthogonal handles for further functionalization, while the compound exhibits good bench stability and compatibility with standard purification protocols. It functions as a key intermediate in the synthesis of bioactive heterocycles and API scaffolds.

General Information

  • CAS No. 1805511-17-4
  • Cat. No. CS-0492299
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrF₃N₂
  • Molecular Weight 241.01
  • Synonym(s) None
  • SMILES NC1=C(Br)C(=NC=C1)C(F)(F)F

Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.4451
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

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GHS Pictogram : N/A
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Signal Word : N/A
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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