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Structure of 1807501-82-1
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endo-BCN-PEG3-acid features a strained cyclooctyne warhead paired with a triethylene glycol spacer and terminal carboxylic acid functionality. This design enables rapid, bioorthogonal conjugation under physiological conditions, ideal for labeling biomolecules or immobilizing probes in aqueous environments. The PEG3 linker enhances solubility and reduces nonspecific binding.
endo-BCN-PEG3-acid serves as a versatile, bench-stable bifunctional linker for site-specific conjugation in bioconjugate chemistry. The norbornene moiety enables efficient inverse electron-demand Diels-Alder (IEDDA) ligation with tetrazines under physiological conditions, while the terminal carboxylic acid facilitates amide coupling or activation via standard EDC/NHS protocols. The PEG3 spacer provides solubility and reduces steric hindrance, enhancing reactivity and compatibility in protein labeling, probe synthesis, and macrocyclic scaffold construction.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: