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CS-W001157 4
Total: USD 88.00

endo-BCN-PEG3-acid

  • CAS No. 1807501-82-1

  • Cat. No. CS-0109343
  • Purity≥98%
  • MDL No.MFCD31692198
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

endo-BCN-PEG3-acid|CS-0109343

Structure of 1807501-82-1

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Description

endo-BCN-PEG3-acid features a strained cyclooctyne warhead paired with a triethylene glycol spacer and terminal carboxylic acid functionality. This design enables rapid, bioorthogonal conjugation under physiological conditions, ideal for labeling biomolecules or immobilizing probes in aqueous environments. The PEG3 linker enhances solubility and reduces nonspecific binding.

Application

endo-BCN-PEG3-acid serves as a versatile, bench-stable bifunctional linker for site-specific conjugation in bioconjugate chemistry. The norbornene moiety enables efficient inverse electron-demand Diels-Alder (IEDDA) ligation with tetrazines under physiological conditions, while the terminal carboxylic acid facilitates amide coupling or activation via standard EDC/NHS protocols. The PEG3 spacer provides solubility and reduces steric hindrance, enhancing reactivity and compatibility in protein labeling, probe synthesis, and macrocyclic scaffold construction.

General Information

  • CAS No. 1807501-82-1
  • Cat. No. CS-0109343
  • Purity ≥98%
  • MDL No. MFCD31692198
  • Storage 4°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₃₁NO₇
  • Molecular Weight 397.46
  • Synonym(s) None
  • SMILES O=C(OCC1C2CCC#CCCC12)NCCOCCOCCOCCC(O)=O

Computational Chemistry Data

  • TPSA   103.32
  • LogP   1.6767
  • H_Acceptors   6
  • H_Donors   2
  • Rotatable_Bonds   14

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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