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Bromo-PEG1-C2-Boc

  • CAS No. 1393330-36-3

  • Cat. No. CS-0114592
  • Molecule weight253.13
  • Purity≥95%
  • MDL No.MFCD22574803

*For research and further manufacturing use only, not for direct human use.

Bromo-PEG1-C2-Boc|CS-0114592

Structure of 1393330-36-3

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General Information

  • CAS No. 1393330-36-3
  • Cat. No. CS-0114592
  • Purity ≥95%
  • MDL No. MFCD22574803
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₇BrO₃
  • Molecular Weight 253.13
  • Synonym(s) tert-Butyl 3-(2-bromoethoxy)propanoate
  • SMILES O=C(OC(C)(C)C)CCOCCBr

Description

Bromo-PEG1-C2-Boc features a reactive bromide handle appended to a short PEG spacer, terminating in a stable Boc protecting group. This design enables selective conjugation under mild conditions while maintaining stability during storage and handling. The molecule integrates seamlessly into peptide and biomolecule synthesis workflows.

Application

Bromo-PEG1-C2-Boc serves as a versatile bifunctional building block for conjugation and macrocyclization strategies. The bromo group enables efficient coupling via Pd-catalyzed cross-coupling or nucleophilic substitution, while the C2-Boc-protected amine offers orthogonal functionality for selective deprotection and chain extension. Its PEG1 spacer provides enhanced solubility and reduced aggregation in aqueous environments, facilitating handling and purification in synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   2.1297
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   5

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