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Structure of 18206-06-9
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2,6-Dimethylisonicotinaldehyde features a sterically hindered aldehyde group flanked by two methyl substituents at the 2 and 6 positions of the pyridine ring. This configuration enhances stability and directs regioselective reactivity in coupling processes. The electron-rich aromatic core supports efficient participation in transition-metal-catalyzed transformations and enables straightforward incorporation into complex heterocyclic architectures under mild conditions.
2,6-Dimethylisonicotinaldehyde serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling the construction of substituted pyridine scaffolds through standard condensation and coupling reactions. Its ortho-methyl groups enhance bench stability and improve solubility in common organic solvents, while the aldehyde functionality facilitates efficient imine formation, reductive amination, and Ugi-type multicomponent reactions. The compound exhibits excellent functional group tolerance and is well-suited for parallel synthesis campaigns and process-scale applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: