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Structure of 182181-38-0
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3-Fluoro-4-(piperazin-1-yl)benzonitrile features a fluorinated aromatic core paired with a piperazine moiety, delivering enhanced solubility and metabolic stability. This electron-deficient aryl nitrile integrates readily into medicinal chemistry scaffolds, serving as a key building block for kinase inhibitors and CNS-targeted therapeutics.
3-Fluoro-4-(piperazin-1-yl)benzonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical scaffolds. The nitrile group offers high functional group tolerance and facilitates downstream transformations such as amidation or reduction. The piperazinyl moiety provides a polar, basic nitrogen for hydrogen bonding and solubility enhancement. This compound exhibits bench stability and is compatible with standard coupling reactions, making it suitable for parallel synthesis campaigns and API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: