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CS-W001157 4
Total: USD 88.00

(3-Fluoro-4-hydroxyphenyl)boronic acid

  • CAS No. 182344-14-5

  • Cat. No. CS-W013287
  • Purity≥96%
  • MDL No.MFCD06659838

*For research and further manufacturing use only, not for direct human use.

(3-Fluoro-4-hydroxyphenyl)boronic acid|CS-W013287

Structure of 182344-14-5

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General Information

  • CAS No. 182344-14-5
  • Cat. No. CS-W013287
  • Purity ≥96%
  • MDL No. MFCD06659838
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BFO₃
  • Molecular Weight 155.92
  • Synonym(s) Boronic acid, (3-fluoro-4-hydroxyphenyl)-
  • SMILES OB(C1=CC=C(O)C(F)=C1)O

Description

This boronate moiety features a strategically positioned fluorine atom that enhances metabolic stability and modulates electronic properties. The hydroxyl group enables efficient coupling in Suzuki-Miyaura reactions, while the overall structure offers improved solubility and bench stability under standard conditions.

Application

(3-Fluoro-4-hydroxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation with aryl and vinyl halides. The ortho-fluoro substituent enhances metabolic stability in bioactive scaffolds, while the boronic acid and phenolic hydroxyl groups provide orthogonal reactivity for downstream functionalization. Bench-stable and readily purified by recrystallization, it facilitates robust synthesis of fluorinated arenes and heterocyclic intermediates relevant to medicinal chemistry.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -0.7889
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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