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CS-W001157 4
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4-Chloroquinolin-5-amine

  • CAS No. 1824318-74-2

  • Cat. No. CS-0163336
  • Molecule weightNone
  • Purity≥97%
  • MDL No.MFCD20259272

*For research and further manufacturing use only, not for direct human use.

4-Chloroquinolin-5-amine|CS-0163336

Structure of 1824318-74-2

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General Information

  • CAS No. 1824318-74-2
  • Cat. No. CS-0163336
  • Purity ≥97%
  • MDL No. MFCD20259272
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇ClN₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES NC1=C2C(Cl)=CC=NC2=CC=C1

Description

4-Chloroquinolin-5-amine features a chlorinated quinoline scaffold with a strategically positioned amine group, enabling direct incorporation into diverse heterocyclic architectures. This electron-deficient core supports efficient coupling reactions and serves as a key building block in medicinal chemistry. The compound exhibits robust stability under standard conditions, facilitating straightforward handling in synthesis workflows.

Application

4-Chloroquinolin-5-amine serves as a versatile building block in medicinal chemistry, enabling direct incorporation into heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. Its chlorine atom facilitates further functionalization, while the amine group offers site-specific derivatization. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for modular synthesis of quinoline-based API candidates.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.4704
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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