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5-Chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3-amine

  • CAS No. 1832583-43-3

  • Cat. No. CS-0131216
  • Purity≥97%
  • MDL No.MFCD29921292
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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3-amine|CS-0131216

Structure of 1832583-43-3

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Description

5-Chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3-amine features a chlorinated pyridine core paired with a 1,2,3-triazole handle, enabling efficient coupling in bioconjugation and medicinal chemistry. The electron-deficient triazole moiety facilitates click reactions under mild conditions, while the amine group offers a versatile anchor for further derivatization. This compound demonstrates excellent stability and solubility in common organic solvents.

Application

5-Chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of triazolyl-pyridine scaffolds via Pd-catalyzed cross-coupling. The chloropyridine moiety facilitates reliable C–N and C–C bond formation under standard conditions, while the 2H-1,2,3-triazole group offers enhanced solubility and hydrogen-bonding capacity. Its bench-stable nature and compatibility with diverse functional groups make it ideal for modular synthesis of bioactive molecules.

General Information

  • CAS No. 1832583-43-3
  • Cat. No. CS-0131216
  • Purity ≥97%
  • MDL No. MFCD29921292
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClN₅
  • Molecular Weight 195.61
  • Synonym(s) 5-chloro-6-(triazol-2-yl)pyridin-3-amine
  • SMILES NC1=CC(Cl)=C(N2N=CC=N2)N=C1

Computational Chemistry Data

  • TPSA   69.62
  • LogP   0.8979
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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