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Structure of 183610-70-0
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3-(Trifluoromethyl)pyridin-2-amine features a trifluoromethyl group at the 3-position and an amine at the 2-position of the pyridine ring, creating a unique electronic profile. This combination enhances solubility in organic solvents while maintaining stability under standard bench conditions. The molecule integrates readily into pharmaceutical scaffolds and serves as a key intermediate in the synthesis of bioactive compounds, particularly those requiring electron-deficient heterocyclic systems.
3-(Trifluoromethyl)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized heterocycles through standard coupling and electrophilic substitution reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the pyridin-2-amine moiety provides a reliable handle for further derivatization via Suzuki-Miyaura, Buchwald-Hartwig, or reductive amination protocols. The compound exhibits good bench stability and is compatible with diverse reaction conditions, facilitating streamlined synthesis of advanced intermediates and API candidates.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H317-H319
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Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: