2-Chloro-6-hydroxybenzaldehyde

Name: 2-Chloro-6-hydroxybenzaldehyde
Brand: ChemScene
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CAS No. 18362-30-6
Cat. No. CS-W017992
Purity≥97%
MDL No.MFCD01646166

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-6-hydroxybenzaldehyde|CS-W017992

Structure of 18362-30-6

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Description

2-Chloro-6-hydroxybenzaldehyde features a hydroxyl group flanked by electron-withdrawing chlorine and aldehyde functionalities, enabling selective functionalization in aromatic synthesis. This ortho-directed reactivity profile supports efficient coupling processes under mild conditions.

Application

2-Chloro-6-hydroxybenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct functionalization at the aromatic ring due to its complementary electron-withdrawing chlorine and reactive aldehyde group. The hydroxyl moiety provides a handle for derivatization or protection, while the aldehyde facilitates reductive amination, Schiff base formation, or coupling reactions. Its bench-stable nature and compatibility with standard synthetic protocols make it well-suited for modular scaffold construction in multi-step sequences.

General Information

CAS No. 18362-30-6
Cat. No. CS-W017992
Purity ≥97%
MDL No. MFCD01646166
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅ClO₂
Molecular Weight 156.57
Synonym(s) 6-Chlorosalicylaldehyde
SMILES ClC1=C(C=O)C(=CC=C1)O

Computational Chemistry Data

TPSA 37.3
LogP 1.8581
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 1759
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Aldehyde

Key Words

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2-Chloro-6-hydroxybenzaldehyde

CAS No. 18362-30-6

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