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CS-W001157 4
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6-Chloro-7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid

  • CAS No. 183736-74-5

  • Cat. No. CS-0213509
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-Chloro-7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid|CS-0213509

Structure of 183736-74-5

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Description

6-Chloro-7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid features a fused chromenone scaffold with orthogonal functional groups enabling diverse derivatization. The electron-deficient aromatic ring pairs with a phenolic hydroxyl and carboxylic acid for enhanced reactivity in coupling and cyclization processes. This bench-stable, moisture-tolerant compound serves as a key intermediate in the synthesis of bioactive heterocycles and natural product analogs.

Application

6-Chloro-7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid serves as a versatile scaffold for the synthesis of bioactive chromenone derivatives. Its ortho-hydroxyketone motif enables facile cyclization and metal-catalyzed coupling reactions, while the carboxylic acid group supports derivatization via amide or ester formation. The molecule exhibits bench stability and tolerates common functional groups, facilitating efficient access to substituted coumarin-based building blocks used in medicinal chemistry and materials science.

General Information

  • CAS No. 183736-74-5
  • Cat. No. CS-0213509
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₅ClO₅
  • Molecular Weight 240.60
  • Synonym(s) CHCC Acid [6-Chloro-7-hydroxycouMarin-3-carboxylic acid]
  • SMILES O=C(C1=CC2=CC(Cl)=C(O)C=C2OC1=O)O

Computational Chemistry Data

  • TPSA   87.74
  • LogP   1.8502
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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