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Structure of 101012-12-8
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2-Chlorothiazole-5-carboxylic acid features a chlorine-substituted thiazole ring fused to a carboxylic acid group, enabling direct functionalization in heterocyclic synthesis. This electron-deficient scaffold integrates readily into bioactive molecules and serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and antimicrobial agents.
2-Chlorothiazole-5-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of thiazole-based scaffolds through standard coupling and functionalization reactions. Its carboxylic acid group facilitates direct amidation or esterification, while the chlorine substituent provides a site for nucleophilic substitution under mild conditions. The compound exhibits good bench stability and is compatible with common protecting group strategies, making it suitable for iterative synthetic sequences in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: