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Structure of 183803-06-7
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5-Iodo-2-methylphenol features a strategically positioned iodine atom and methyl group on a phenolic scaffold, enabling direct functionalization in cross-coupling reactions. The electron-rich aromatic ring facilitates palladium-catalyzed transformations, while the hydroxyl group provides a handle for derivatization. This compound offers enhanced stability under standard conditions and serves as a key intermediate in medicinal chemistry and materials science applications.
5-Iodo-2-methylphenol serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions such as Suzuki, Stille, and Negishi couplings. The iodide group offers high reactivity under mild conditions, while the ortho-methyl and phenolic hydroxyl functionalities provide steric and electronic modulation. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient synthesis of complex heterocyclic scaffolds and bioactive molecules.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: