rel-tert-Butyl (2R,6R)-2,6-dimethyl-4-oxopiperidine-1-carboxylate

Name: rel-tert-Butyl (2R,6R)-2,6-dimethyl-4-oxopiperidine-1-carboxylate
Brand: ChemScene
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CAS No. 184368-70-5
Cat. No. CS-0140256
Purity≥98%
MDL No.None

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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rel-tert-Butyl (2R,6R)-2,6-dimethyl-4-oxopiperidine-1-carboxylate|CS-0140256

Structure of 184368-70-5

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General Information

CAS No. 184368-70-5
Cat. No. CS-0140256
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₁NO₃
Molecular Weight 227.30
Synonym(s) trans-2,6-Dimethylpiperidin-4-one,N-BOCprotected
SMILES O=C(N1[C@H](C)CC(C[C@H]1C)=O)OC(C)(C)C

Description

rel-tert-Butyl (2R,6R)-2,6-dimethyl-4-oxopiperidine-1-carboxylate is a stereochemically defined piperidine derivative featuring a bench-stable tert-butyl ester and two methyl groups at the 2- and 6-positions. This configuration enables direct incorporation into asymmetric synthesis workflows, where it serves as a chiral building block for complex heterocycles and bioactive molecule scaffolds.

Application

rel-tert-Butyl (2R,6R)-2,6-dimethyl-4-oxopiperidine-1-carboxylate serves as a stable, bench-ready chiral building block for the synthesis of piperidine-based scaffolds. Its defined stereochemistry and protected carbonyl group enable selective functionalization in late-stage diversification. The tert-butyl ester facilitates straightforward deprotection under mild acidic conditions, while the methyl groups at C2 and C6 enhance conformational rigidity and metabolic stability—key attributes in medicinal chemistry lead optimization.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 46.61
LogP 2.3634
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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rel-tert-Butyl (2R,6R)-2,6-dimethyl-4-oxopiperidine-1-carboxylate

CAS No. 184368-70-5

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