Benzothiophene-3-sulfonyl chloride

Name: Benzothiophene-3-sulfonyl chloride
Brand: ChemScene
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CAS No. 18494-87-6
Cat. No. CS-W009496
Purity≥98%
MDL No.MFCD02681897

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Benzothiophene-3-sulfonyl chloride|CS-W009496

Structure of 18494-87-6

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Description

Benzothiophene-3-sulfonyl chloride features a reactive sulfonyl chloride group flanked by an electron-rich benzothiophene core, enabling direct incorporation into sulfonamide derivatives. This bench-stable reagent facilitates efficient coupling under mild conditions, delivering high-yield functionalization in synthetic and medicinal chemistry workflows.

Application

Benzothiophene-3-sulfonyl chloride serves as a versatile acylating agent for the introduction of a benzothiophene-3-sulfonyl group into diverse molecular scaffolds. It enables efficient formation of sulfonamides and sulfonate esters under mild conditions, demonstrating good bench stability and compatibility with common functional groups. This reagent facilitates access to key intermediates in medicinal chemistry campaigns, particularly in kinase inhibitor and GPCR-targeted drug discovery, where the sulfonyl moiety contributes to target binding affinity and metabolic stability.

General Information

CAS No. 18494-87-6
Cat. No. CS-W009496
Purity ≥98%
MDL No. MFCD02681897
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅ClO₂S₂
Molecular Weight 232.70
Synonym(s) 1-Benzothiophene-3-sulfonyl chloride
SMILES ClS(=O)(=O)C1=CSC2=CC=CC=C12

Computational Chemistry Data

TPSA 34.14
LogP 2.8288
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Benzothiophene compounds

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Benzothiophene-3-sulfonyl chloride

CAS No. 18494-87-6

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