2,3-Dihydro-benzo[1,4]dioxine-6-sulfonyl chloride

Name: 2,3-Dihydro-benzo[1,4]dioxine-6-sulfonyl chloride
Brand: ChemScene
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CAS No. 63758-12-3
Cat. No. CS-0071523
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,3-Dihydro-benzo[1,4]dioxine-6-sulfonyl chloride|CS-0071523

Structure of 63758-12-3

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Description

2,3-Dihydro-benzo[1,4]dioxine-6-sulfonyl chloride features a reactive sulfonyl chloride group attached to a stable dihydrobenzodioxine scaffold. This configuration enables selective coupling in synthetic routes requiring sulfonamide formation under mild conditions. The molecule exhibits enhanced solubility in polar organic solvents and demonstrates robust stability during handling, facilitating integration into complex molecular architectures.

Application

2,3-Dihydro-benzo[1,4]dioxine-6-sulfonyl chloride serves as a versatile sulfonylating agent for the introduction of sulfonate groups into diverse substrates. Its benzo[1,4]dioxine core provides structural rigidity and metabolic stability, while the reactive sulfonyl chloride moiety enables efficient coupling with amines, alcohols, and thiols under mild conditions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for use in medicinal chemistry and process development workflows requiring selective sulfonation.

General Information

CAS No. 63758-12-3
Cat. No. CS-0071523
Purity ≥95%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₇ClO₄S
Molecular Weight 234.66
Synonym(s) 2,3-Dihydro-1,4-benzodioxine-6-sulfonyl chloride
SMILES O=S(C1=CC(OCCO2)=C2C=C1)(Cl)=O

Computational Chemistry Data

TPSA 52.6
LogP 1.3853
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Benzodioxane compounds

Key Words

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2,3-Dihydro-benzo[1,4]dioxine-6-sulfonyl chloride

CAS No. 63758-12-3

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