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CS-W001157 4
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6-(2,6-Dichlorophenyl)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

  • CAS No. 185039-48-9

  • Cat. No. CS-0360873
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-(2,6-Dichlorophenyl)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one|CS-0360873

Structure of 185039-48-9

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General Information

  • CAS No. 185039-48-9
  • Cat. No. CS-0360873
  • Purity ≥97%
  • MDL No. None
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₁Cl₂N₃O₃S
  • Molecular Weight 384.24
  • Synonym(s) 6-(2,6-Dichlorophenyl)-8-methyl-2-methylsulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one
  • SMILES CN1C2=NC(=NC=C2C=C(C3=C(C=CC=C3Cl)Cl)C1=O)S(=O)(=O)C

Synthesis

  • Route1
    • 6-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one|CS-0572453
      185039-46-7
    • ~99%
    • 6-(2,6-Dichlorophenyl)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one|CS-0360873
      185039-48-9

    References

    • SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH Patent: WO2004/63195 A1, 2004 ; Location in patent: Page 53; 55-56 ; WO 2004/063195 A1
  • Route2

    References

    • Klutchko, Sylvester R.; Hamby, James M.; Boschelli, Diane H.; Wu, Zhipei; Kraker, Alan J.; Amar, Aneesa M.; Hartl, Brian G.; Shen, Cynthia; Klohs, Wayne D.; Steinkampf, Randall W.; Driscoll, Denise L.; Nelson, James M.; Elliott, William L.; Roberts, Billy J.; Stoner, Chad L.; Vincent, Patrick W.; Dykes, Donald J.; Panek, Robert L.; Lu, Gina H.; Major, Terry C.; Dahring, Tawny K.; Hallak, Hussein; Bradford, Laura A.; Showalter, H. D. Hollis; Doherty, Annette M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 17 p. 3276 - 3292
  • Route3

    References

    • Klutchko, Sylvester R.; Hamby, James M.; Boschelli, Diane H.; Wu, Zhipei; Kraker, Alan J.; Amar, Aneesa M.; Hartl, Brian G.; Shen, Cynthia; Klohs, Wayne D.; Steinkampf, Randall W.; Driscoll, Denise L.; Nelson, James M.; Elliott, William L.; Roberts, Billy J.; Stoner, Chad L.; Vincent, Patrick W.; Dykes, Donald J.; Panek, Robert L.; Lu, Gina H.; Major, Terry C.; Dahring, Tawny K.; Hallak, Hussein; Bradford, Laura A.; Showalter, H. D. Hollis; Doherty, Annette M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 17 p. 3276 - 3292

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   81.92
  • LogP   2.7058
  • H_Acceptors   6
  • H_Donors   0
  • Rotatable_Bonds   2

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