1-Bromo-2-fluoro-4-nitrobenzene

Name: 1-Bromo-2-fluoro-4-nitrobenzene
Brand: ChemScene
Availability: InStock
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CAS No. 185331-69-5
Cat. No. CS-W014261
Purity≥97%
MDL No.MFCD05865088

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-Bromo-2-fluoro-4-nitrobenzene|CS-W014261

Structure of 185331-69-5

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Description

1-Bromo-2-fluoro-4-nitrobenzene features a trifunctional aryl scaffold with complementary electrophilic and electron-withdrawing groups. The bromine site enables palladium-catalyzed cross-coupling, while the ortho-fluorine facilitates nucleophilic aromatic substitution. This combination delivers efficient access to complex heterocycles and functionalized biaryls under mild conditions.

Application

1-Bromo-2-fluoro-4-nitrobenzene serves as a versatile building block in nucleophilic aromatic substitution (SNAr) reactions, enabling efficient access to functionalized aryl intermediates. The ortho-fluorine and para-bromine substituents provide orthogonal reactivity, facilitating sequential substitutions under mild conditions. Its bench-stable nature and compatibility with diverse nucleophiles—such as amines, thiols, and alkoxides—make it ideal for constructing complex heterocycles and pharmaceutical scaffolds in medicinal chemistry workflows.

General Information

CAS No. 185331-69-5
Cat. No. CS-W014261
Purity ≥97%
MDL No. MFCD05865088
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃BrFNO₂
Molecular Weight 220.00
Synonym(s) 4-Bromo-3-fluoronitrobenzene
SMILES FC1=CC([N+]([O-])=O)=CC=C1Br

Computational Chemistry Data

TPSA 43.14
LogP 2.4964
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Nitro compounds

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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1-Bromo-2-fluoro-4-nitrobenzene

CAS No. 185331-69-5

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