2-Amino-5-chloro-3-fluorophenol

Name: 2-Amino-5-chloro-3-fluorophenol
Brand: ChemScene
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CAS No. 186309-72-8
Cat. No. CS-0163593
Purity≥97%
MDL No.MFCD25978072

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Amino-5-chloro-3-fluorophenol|CS-0163593

Structure of 186309-72-8

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Description

2-Amino-5-chloro-3-fluorophenol features a trifunctional aromatic core with complementary reactivity. The electron-rich amine group pairs with the ortho-fluoro substituent to enable selective coupling, while the chlorine atom provides a handle for palladium-catalyzed cross-coupling. This scaffold delivers high functional group tolerance and stability under standard bench conditions.

Application

2-Amino-5-chloro-3-fluorophenol serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive scaffolds. Its ortho-halogenated phenolic framework facilitates palladium-catalyzed cross-coupling reactions and electrophilic substitution, while the amino and hydroxyl groups offer orthogonal functionalization pathways. The compound exhibits good bench stability and is amenable to standard purification techniques, supporting scalable synthesis of pharmaceutical intermediates.

General Information

CAS No. 186309-72-8
Cat. No. CS-0163593
Purity ≥97%
MDL No. MFCD25978072
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅ClFNO
Molecular Weight 161.56
Synonym(s) None
SMILES OC1=CC(Cl)=CC(F)=C1N

Computational Chemistry Data

TPSA 46.25
LogP 1.7669
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Phenol

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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2-Amino-5-chloro-3-fluorophenol

CAS No. 186309-72-8

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