7-(Benzenesulfonyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

Name: 7-(Benzenesulfonyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
Brand: ChemScene
Availability: OutOfStock
Rating: 5 (1 reviews)

CAS No. 186519-89-1
Cat. No. CS-0050136
Purity≥98%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

7-(Benzenesulfonyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine|CS-0050136

Structure of 186519-89-1

Size

Price

Quantity

* Please select Quantity before adding items.

Description

7-(Benzenesulfonyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine is a bench-stable heterocyclic scaffold featuring a chloro substituent at the 4-position and a benzenesulfonyl group at the 7-position. This configuration imparts enhanced solubility and electronic modulation, enabling efficient coupling in transition-metal-catalyzed reactions. The molecule integrates readily into kinase inhibitor scaffolds and serves as a key intermediate in medicinal chemistry campaigns targeting ATP-binding sites.

Application

7-(Benzenesulfonyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of purine-derived scaffolds. The 4-chloro substituent facilitates nucleophilic substitution reactions with amines and heterocycles, while the benzenesulfonyl group enhances solubility and modulates electronic properties. This compound exhibits excellent bench stability and is compatible with standard coupling protocols, making it well-suited for parallel synthesis campaigns targeting kinase inhibitors and other bioactive heterocycles.

General Information

CAS No. 186519-89-1
Cat. No. CS-0050136
Purity ≥98%
MDL No. None
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₈ClN₃O₂S
Molecular Weight 293.73
Synonym(s) 4-Chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-D]pyrimidine
SMILES ClC1=C2C=CN(C2=NC=N1)S(=O)(=O)C1=CC=CC=C1

Computational Chemistry Data

TPSA 64.85
LogP 2.3217
H_Acceptors 5
H_Donors 0
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrrole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

186519-89-1 sigma186519-89-1 manufacturer186519-89-1 price186519-89-1 structure186519-89-1 SDSbuy 186519-89-1186519-89-1 supplier186519-89-1 uses186519-89-1 molecular weightprice of 186519-89-1186519-89-1 chemical name formula of 186519-89-1

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

7-(Benzenesulfonyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

CAS No. 186519-89-1

Recommended Products