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CS-W001157 4
Total: USD 88.00

4-Fluoro-2-hydroxybenzonitrile

  • CAS No. 186590-01-2

  • Cat. No. CS-0044038
  • Purity≥98%
  • MDL No.MFCD13185487
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-2-hydroxybenzonitrile|CS-0044038

Structure of 186590-01-2

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Description

4-Fluoro-2-hydroxybenzonitrile features a strategically positioned hydroxyl group flanked by electron-withdrawing fluorine and nitrile moieties, enabling robust participation in cross-coupling and electrophilic substitution reactions. This ortho-hydroxylated aromatic scaffold exhibits enhanced reactivity and stability under standard conditions, facilitating efficient integration into complex molecular architectures.

Application

4-Fluoro-2-hydroxybenzonitrile serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic hydroxyl and nitrile groups. Its ortho-hydroxy and meta-fluoro substitution pattern facilitates regioselective derivatization, including nucleophilic aromatic substitution and transition-metal-catalyzed coupling reactions. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for use in API intermediate synthesis and heterocyclic scaffold construction.

General Information

  • CAS No. 186590-01-2
  • Cat. No. CS-0044038
  • Purity ≥98%
  • MDL No. MFCD13185487
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄FNO
  • Molecular Weight 137.11
  • Synonym(s) None
  • SMILES N#CC1=CC=C(F)C=C1O

Computational Chemistry Data

  • TPSA   44.02
  • LogP   1.40298
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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