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Structure of 186590-04-5
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4-Fluoro-3-hydroxybenzonitrile features a strategically positioned hydroxyl group flanked by fluorine and nitrile functionalities, enabling direct incorporation into bioactive scaffolds. The electron-withdrawing nitrile and fluorine atoms enhance metabolic stability while maintaining solubility under standard conditions. This ortho-substituted aryl system serves as a key building block for pharmaceutical intermediates and functionalized heterocycles.
4-Fluoro-3-hydroxybenzonitrile serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic hydroxyl group and facilitating downstream coupling reactions. Its ortho-fluorine and nitrile groups provide orthogonal reactivity for palladium-catalyzed cross-couplings and nucleophilic substitutions. Bench-stable and amenable to purification via recrystallization, it functions reliably in the synthesis of heterocyclic scaffolds and bioactive intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: