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CS-W001157 4
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2-Methyl-3-nitropyridine

  • CAS No. 18699-87-1

  • Cat. No. CS-D0206
  • Purity≥98%
  • MDL No.MFCD04114137

*For research and further manufacturing use only, not for direct human use.

2-Methyl-3-nitropyridine|CS-D0206

Structure of 18699-87-1

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General Information

  • CAS No. 18699-87-1
  • Cat. No. CS-D0206
  • Purity ≥98%
  • MDL No. MFCD04114137
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O₂
  • Molecular Weight 138.12
  • Synonym(s) 3-Nitro-2-picoline; Pyridine, 2-methyl-3-nitro- (9CI)
  • SMILES CC1=NC=CC=C1[N+]([O-])=O

Description

2-Methyl-3-nitropyridine features a nitro group at the 3-position and a methyl substituent at the 2-position of the pyridine ring, creating a sterically hindered, electron-deficient heterocycle. This combination enhances stability and directs electrophilic substitution regioselectively, making it valuable for synthesizing advanced pharmaceutical intermediates and functionalized ligands in catalysis.

Application

2-Methyl-3-nitropyridine serves as a versatile heterocyclic building block in medicinal chemistry and agrochemical synthesis. Its nitro group enables electrophilic substitution, while the methyl substituent provides a handle for directed metalation or oxidation to carboxylic acid derivatives. The compound exhibits bench stability, facilitates straightforward purification, and participates reliably in Pd-catalyzed cross-coupling reactions, making it well-suited for constructing complex nitrogen-containing scaffolds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.29822
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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