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CS-W001157 4
Total: USD 88.00

2-(4-Methoxyphenoxy)acetic acid

  • CAS No. 1877-75-4

  • Cat. No. CS-W008390
  • Molecule weight182.17
  • Purity≥98%
  • MDL No.MFCD00014360

*For research and further manufacturing use only, not for direct human use.

2-(4-Methoxyphenoxy)acetic acid|CS-W008390

Structure of 1877-75-4

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General Information

  • CAS No. 1877-75-4
  • Cat. No. CS-W008390
  • Purity ≥98%
  • MDL No. MFCD00014360
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O₄
  • Molecular Weight 182.17
  • Synonym(s) p-Methoxyphenoxyacetic acid
  • SMILES O=C(O)COC1=CC=C(OC)C=C1

Description

This 2-(4-methoxyphenoxy)acetic acid features a polar ether linkage flanked by a phenolic methoxy group and a carboxylic acid terminus, enabling robust conjugation in bioconjugation workflows. The electron-donating methoxy substituent enhances solubility and stability under standard conditions.

Application

2-(4-Methoxyphenoxy)acetic acid serves as a versatile building block for the synthesis of bioactive molecules, particularly in medicinal chemistry and agrochemical research. Its phenolic ether functionality enables reliable coupling reactions, while the carboxylic acid group facilitates amide, ester, and salt formation under standard conditions. The compound exhibits good bench stability and is readily purified by recrystallization or chromatography, making it well-suited for use in multi-step syntheses and API intermediate development.

Synthesis

  • Route1
    • Ethyl 2-(4-methoxyphenoxy)acetate|CS-0328446
      18598-23-7
    • ~78%
    • In-stock
      2-(4-Methoxyphenoxy)acetic acid|CS-W008390
      1877-75-4

    References

    • Benjamin, Iris; Hong, Haiping; Avny, Yair; Davidov, Dan; Neumann, Ronny Journal of Materials Chemistry, 1998 , vol. 8, # 4 p. 919 - 924
  • Route2
    • In-stock
      Mequinol|CS-W019963
      150-76-5
    • null|null
      79-11-8
    • ~95%
    • In-stock
      2-(4-Methoxyphenoxy)acetic acid|CS-W008390
      1877-75-4

    References

    • Villemin, Didier; Hammadi, Mohamed Synthetic Communications, 1996 , vol. 26, # 23 p. 4337 - 4341
  • Route3
    • null|null
      3926-62-3
    • In-stock
      Mequinol|CS-W019963
      150-76-5
    • ~86%
    • In-stock
      2-(4-Methoxyphenoxy)acetic acid|CS-W008390
      1877-75-4

    References

    • Jimenez, Fabiola; Cruz, Maria Del Carmen; Zuniga, Clara; Martinez, Maria A.; Chamorro, German; Diaz, Francisco; Tamariz, Joaquin Medicinal Chemistry Research, 2010 , vol. 19, # 1 p. 33 - 57

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.76
  • LogP   1.1586
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   4

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