1-Boc-4-Methylpiperidine-4-carboxylic acid

Name: 1-Boc-4-Methylpiperidine-4-carboxylic acid
Brand: ChemScene
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CAS No. 189321-63-9
Cat. No. CS-M0704
Purity≥97%
MDL No.MFCD02179132

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-Boc-4-Methylpiperidine-4-carboxylic acid|CS-M0704

Structure of 189321-63-9

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Description

1-Boc-4-Methylpiperidine-4-carboxylic acid features a sterically hindered piperidine core with a stable Boc-protected carboxylic acid moiety, enabling direct incorporation into peptide and macrocyclic scaffolds. The methyl group enhances conformational rigidity, while the bench-stable protection simplifies handling and purification under standard conditions.

Application

1-Boc-4-methylpiperidine-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of piperidine-based scaffolds with enhanced metabolic stability. The Boc group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. Its methylated C4 position imparts conformational rigidity, while the carboxylic acid functionality supports efficient coupling reactions, making it ideal for peptide and macrocycle assembly.

General Information

CAS No. 189321-63-9
Cat. No. CS-M0704
Purity ≥97%
MDL No. MFCD02179132
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₁NO₄
Molecular Weight 243.30
Synonym(s) 1-N-Boc-4-Methyl-Piperidine-4-Carboxylic Acid
SMILES O=C(OC(C)(C)C)N1CCC(C(O)=O)(C)CC1

Computational Chemistry Data

TPSA 66.84
LogP 2.1082
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Unnatural Amino Acid Derivatives

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1-Boc-4-Methylpiperidine-4-carboxylic acid

CAS No. 189321-63-9

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