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CS-W001157 4
Total: USD 88.00

N-(Phenylsulfonyl)-N-((trifluoromethyl)thio)benzenesulfonamide

  • CAS No. 1902154-93-1

  • Cat. No. CS-0460082
  • Molecule weight397.41
  • Purity≥98%
  • MDL No.MFCD31568557

*For research and further manufacturing use only, not for direct human use.

N-(Phenylsulfonyl)-N-((trifluoromethyl)thio)benzenesulfonamide|CS-0460082

Structure of 1902154-93-1

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General Information

  • CAS No. 1902154-93-1
  • Cat. No. CS-0460082
  • Purity ≥98%
  • MDL No. MFCD31568557
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₀F₃NO₄S₃
  • Molecular Weight 397.41
  • Synonym(s) None
  • SMILES O=S(C1=CC=CC=C1)(N(S(=O)(C2=CC=CC=C2)=O)SC(F)(F)F)=O

Description

N-(Phenylsulfonyl)-N-((trifluoromethyl)thio)benzenesulfonamide features a dual sulfonamide architecture with orthogonal electron-withdrawing groups: a phenylsulfonyl moiety and a trifluoromethylthio substituent. This combination imparts high stability and enhanced electrophilicity, enabling efficient incorporation into complex molecular scaffolds under mild conditions. The molecule’s robustness facilitates use in iterative synthetic sequences without degradation.

Application

N-(Phenylsulfonyl)-N-((trifluoromethyl)thio)benzenesulfonamide serves as a stable, bench-ready sulfonamide building block enabling selective C–H functionalization and heterocycle synthesis. Its dual sulfonamide architecture provides orthogonal reactivity for late-stage modifications, while the trifluoromethylthio group enhances metabolic stability and lipophilicity in medicinal chemistry applications. The molecule exhibits excellent functional group tolerance and facilitates efficient purification via crystallization or column chromatography.

Safety Information

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GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 2920
Class : 8
Packing Group : Ⅱ
Hazard Statements : H228-H314
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   71.52
  • LogP   3.2342
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   5

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