Lot numbers can be found on the outside label of a product:
tert-Butyl 5-oxo-1,4-diazepane-1-carboxylate
-
CAS No. 190900-21-1
- Cat. No. CS-W004238
- Purity≥95%
- MDL No.MFCD04115319
*For research and further manufacturing use only, not for direct human use.
Structure of 190900-21-1
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 190900-21-1
- Cat. No. CS-W004238
- Purity ≥95%
- MDL No. MFCD04115319
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₈N₂O₃
- Molecular Weight 214.26
- Synonym(s) tert-Butyl-5-oxo-1,4-diazepan-1-carboxylat
- SMILES O=C1NCCN(CC1)C(=O)OC(C)(C)C
Description
tert-Butyl 5-oxo-1,4-diazepane-1-carboxylate features a stable, bench-ready carbamate protecting group and a ketone-functionalized diazepane core. This scaffold enables direct incorporation into complex heterocyclic systems, particularly in medicinal chemistry applications requiring nitrogen-rich ring architectures. The molecule's defined polarity and compatibility with standard coupling protocols streamline synthetic access to bioactive analogs.
Application
tert-Butyl 5-oxo-1,4-diazepane-1-carboxylate serves as a versatile scaffold for the synthesis of biologically relevant heterocycles, enabling efficient access to nitrogen-containing ring systems. Its ketone functionality at C5 facilitates selective transformations such as reductive amination and nucleophilic addition, while the tert-butyl ester group provides stability and ease of removal under mild acidic conditions. The molecule exhibits robust bench stability and functional group tolerance, making it well-suited for iterative synthetic strategies in medicinal chemistry and process development.
Synthesis
-
Route1
-
In-stock
150008-24-5 - ~83%
-
In-stock
190900-21-1
References
-
Augustine, John Kallikat; Kumar, Rajesha; Bombrun, Agnes; Mandal, Ashis Baran Tetrahedron Letters, 2011 , vol. 52, # 10 p. 1074 - 1077
-
-
References
-
LEO PHARMA A/S; NIELSEN, Simon, Feldbaek; GREVE, Daniel, Rodriguez; GRUE-SOERENSEN, Gunnar; RYTTERSGAARD, Carsten; SCHOU, Soeren, Christian; SAMS, Anette, Graven Patent: WO2012/3829 A1, 2012 ; Location in patent: Page/Page column 59 ; WO 2012/003829 A1
-
-
Route3
-
190900-20-0 -
In-stock
24424-99-5 - ~89%
-
In-stock
190900-21-1
References
-
Merck and Co., Inc. Patent: US6372733 B1, 2002 ; Location in patent: Example 1 ;
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 58.64
- LogP 0.7434
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 190900-21-1 sigma190900-21-1 manufacturer190900-21-1 price190900-21-1 structure190900-21-1 SDSbuy 190900-21-1190900-21-1 supplier190900-21-1 uses190900-21-1 molecular weightprice of 190900-21-1190900-21-1 chemical name formula of 190900-21-1