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Structure of 191330-98-0
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Methyl 2-bromo-3,3-dimethoxypropanoate features a bromine-substituted carbon adjacent to a geminal dimethoxy group, enabling efficient C–C bond formation in cross-coupling reactions. The ester functionality offers solubility in common organic solvents and compatibility with palladium-catalyzed transformations under mild conditions. This reagent serves as a versatile synthon for constructing complex molecular architectures in synthetic organic chemistry.
Methyl 2-bromo-3,3-dimethoxypropanoate serves as a versatile synthon for C–C bond formation and heterocycle synthesis. The α-bromoester functionality enables efficient Stetter, Reformatsky, and Negishi couplings, while the geminal dimethoxy group stabilizes adjacent carbanions and facilitates subsequent functionalization. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and natural product synthesis.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 1760
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H318-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501
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Lot numbers can be found on the outside label of a product: