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(S)-tert-Butyl 3-formylpyrrolidine-1-carboxylate

  • CAS No. 191348-04-6

  • Cat. No. CS-0079694
  • Purity≥95%
  • MDL No.MFCD14635729

*For research and further manufacturing use only, not for direct human use.

(S)-tert-Butyl 3-formylpyrrolidine-1-carboxylate|CS-0079694

Structure of 191348-04-6

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General Information

  • CAS No. 191348-04-6
  • Cat. No. CS-0079694
  • Purity ≥95%
  • MDL No. MFCD14635729
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₇NO₃
  • Molecular Weight 199.25
  • Synonym(s) tert-butyl (3S)-3-formylpyrrolidine-1-carboxylate
  • SMILES O=C(OC(C)(C)C)N1C[C@@H](C=O)CC1

Description

This chiral pyrrolidine derivative features a formyl group at the 3-position and a tert-butyl carbamate protecting group, enabling direct functionalization in asymmetric synthesis. The bench-stable, moisture-tolerant scaffold facilitates efficient access to bioactive nitrogen heterocycles through reductive amination or nucleophilic addition protocols.

Application

(S)-tert-Butyl 3-formylpyrrolidine-1-carboxylate serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to nitrogen-containing heterocycles. The aldehyde group facilitates standard transformations such as reductive amination, Wittig reactions, and nucleophilic additions, while the protected pyrrolidine scaffold offers excellent functional group tolerance and bench stability. Its well-defined stereochemistry supports asymmetric synthesis workflows, and the tert-butyl carbamate handle simplifies purification and downstream deprotection, making it ideal for iterative library construction and API precursor development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.61
  • LogP   1.4423
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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