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1-Ethyl-1H-imidazole-5-carbaldehyde hydrochloride

  • CAS No. 1914148-58-5

  • Cat. No. CS-0166784
  • Molecule weight160.60
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Ethyl-1H-imidazole-5-carbaldehyde hydrochloride|CS-0166784

Structure of 1914148-58-5

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General Information

  • CAS No. 1914148-58-5
  • Cat. No. CS-0166784
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉ClN₂O
  • Molecular Weight 160.60
  • Synonym(s) None
  • SMILES O=CC1=CN=CN1CC.[H]Cl

Description

1-Ethyl-1H-imidazole-5-carbaldehyde hydrochloride features a reactive aldehyde group flanked by an electron-rich imidazole ring and ethyl substituent. This bench-stable, moisture-tolerant reagent enables direct coupling in amine-functionalization workflows. The protonated imidazole enhances solubility in polar media while maintaining compatibility with standard synthetic protocols.

Application

1-Ethyl-1H-imidazole-5-carbaldehyde hydrochloride serves as a versatile building block for heterocyclic synthesis, enabling efficient access to imidazole-based scaffolds via nucleophilic addition and condensation reactions. The aldehyde functionality offers high reactivity in standard transformations, while the protonated imidazole ring enhances solubility and stability in polar solvents. Its bench-stable form facilitates handling and purification, making it suitable for use in medicinal chemistry campaigns and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   34.89
  • LogP   1.1373
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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