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CS-W001157 4
Total: USD 88.00

3-Aminobenzenesulfonyl fluoride

  • CAS No. 368-50-3

  • Cat. No. CS-0134098
  • Purity≥97%
  • MDL No.MFCD00047847

*For research and further manufacturing use only, not for direct human use.

3-Aminobenzenesulfonyl fluoride|CS-0134098

Structure of 368-50-3

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General Information

  • CAS No. 368-50-3
  • Cat. No. CS-0134098
  • Purity ≥97%
  • MDL No. MFCD00047847
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FNO₂S
  • Molecular Weight None
  • Synonym(s) Benzenesulfonyl fluoride, 3-amino-
  • SMILES O=S(C1=CC=CC(N)=C1)(F)=O

Description

3-Aminobenzenesulfonyl fluoride is a reactive sulfonyl fluoride reagent featuring an electron-rich aromatic amine group. This combination enables selective labeling and covalent modification of nucleophilic residues in proteins and biomolecules under physiological conditions. The molecule integrates seamlessly into probe design workflows, offering enhanced stability and controlled reactivity for chemical biology applications.

Application

3-Aminobenzenesulfonyl fluoride serves as a versatile building block in medicinal chemistry, enabling the direct introduction of both sulfonamide and amine functionalities in a single step. Its reactivity facilitates efficient amide and sulfonamide couplings under mild conditions, with excellent bench stability and compatibility across diverse reaction matrices. The molecule functions as a key intermediate in the synthesis of heterocyclic scaffolds and targeted API candidates, particularly in kinase inhibitor development.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314-H332
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501

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Computational Chemistry Data

  • TPSA   60.16
  • LogP   0.927
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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