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CS-W001157 4
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tert-Butyl 1-oxo-8-azaspiro[4.5]decane-8-carboxylate

  • CAS No. 191805-29-5

  • Cat. No. CS-W000610
  • Molecule weightNone
  • Purity≥95%
  • MDL No.MFCD18074085

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 1-oxo-8-azaspiro[4.5]decane-8-carboxylate|CS-W000610

Structure of 191805-29-5

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General Information

  • CAS No. 191805-29-5
  • Cat. No. CS-W000610
  • Purity ≥95%
  • MDL No. MFCD18074085
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₃NO₃
  • Molecular Weight None
  • Synonym(s) None
  • SMILES O=C(N1CCC2(CC1)CCCC2=O)OC(C)(C)C

Description

tert-Butyl 1-oxo-8-azaspiro[4.5]decane-8-carboxylate is a sterically shielded spirocyclic ketone bearing a bench-stable tert-butyl ester handle. This scaffold integrates a rigid, electron-deficient lactam core with a protected carboxylic acid functionality, enabling direct use in iterative synthesis and late-stage diversification.

Application

tert-Butyl 1-oxo-8-azaspiro[4.5]decane-8-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry and catalytic synthesis. The ketone functionality enables selective reductions, nucleophilic additions, and imine formation, while the protected amine supports sequential functionalization. Its tert-butyl ester facilitates straightforward deprotection under mild acidic conditions, enabling access to bioactive carboxylic acid derivatives. The rigid spirocyclic core enhances conformational control in target-oriented synthesis.

Safety Information

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Computational Chemistry Data

  • TPSA   46.61
  • LogP   2.7567
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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