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CS-W001157 4
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Dibenzofuran-4-ol

  • CAS No. 19261-06-4

  • Cat. No. CS-0060587
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Dibenzofuran-4-ol|CS-0060587

Structure of 19261-06-4

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General Information

  • CAS No. 19261-06-4
  • Cat. No. CS-0060587
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₈O₂
  • Molecular Weight 184.19
  • Synonym(s) 4-Dibenzofuranol
  • SMILES C1=CC=C2C(=C1)C3=C(C(=CC=C3)O)O2

Description

Dibenzofuran-4-ol features a phenolic hydroxyl group at the 4-position of the dibenzofuran core, imparting enhanced polarity and hydrogen-bonding capability. This structural motif enables direct participation in coupling reactions, facilitates solubility in polar solvents, and supports downstream functionalization in medicinal chemistry and materials synthesis.

Application

Dibenzofuran-4-ol serves as a versatile building block in synthetic organic chemistry, offering a rigid, polycyclic scaffold with a phenolic hydroxyl group at the 4-position. Its stability under standard reaction conditions enables direct functionalization via electrophilic substitution or transition-metal-catalyzed coupling. The molecule functions effectively in the construction of bioactive heterocycles and advanced intermediates for pharmaceutical and materials applications, benefiting from straightforward purification and compatibility with common protecting group strategies.

Synthesis

  • Route1

    References

    • MATRIX LABORATORIES LTD. Patent: WO2008/32171 A1, 2008 ; Location in patent: Page/Page column 28-29 ; WO 2008/032171 A1
  • Route2

    References

    • Shultz, David A.; Sloop, Joseph C.; Washington, Gary Journal of Organic Chemistry, 2006 , vol. 71, # 24 p. 9104 - 9113
  • Route3
    • null|null
      41799-27-3
    • ~98%
    • In-stock
      Dibenzofuran-4-ol|CS-0060587
      19261-06-4

    References

    • Oliveira, Ana M. A. G.; Raposo, M. Manuela M.; Oliveira-Campos, Ana M. F.; Griffiths, John; Machado, Antonio E. H. Helvetica Chimica Acta, 2003 , vol. 86, # 8 p. 2900 - 2907

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.37
  • LogP   3.2916
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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